Rotator cuff repair with autologous microfragmented adipose tissue may improve outcomes


Randelli reports receiving consulting fees from DePuy (Johnson & Johnson), Arthrex, MicroPort and Medacta.

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Published results showed intraoperative injection of autologous microfragmented adipose tissue may safely and effectively improve short-term clinical and functional outcomes after single-row arthroscopic rotator cuff repair.

“Although still in the early stages of application, augmentation of rotator cuff repair with autologous microfragmented adipose tissue appears a suitable strategy to enhance tendon repair and regeneration,” Pietro S. Randelli, MD, told Healio.

Randelli and colleagues randomly assigned patients with degenerative posterosuperior rotator cuff tears to receive either a single-row arthroscopic rotator cuff repair alone (control group) or with intraoperative injection of autologous microfragmented adipose tissue processed with an enzyme-free technology (treatment group). Researchers performed clinical follow-up at 3, 6, 12, 18 and 24 months, and obtained MRI of the operated shoulder at 18 months after surgery to assess tendon integrity and re-rupture rate.

Among the 177 patients screened for inclusion, researchers enrolled 52 patients, of whom 44 completed the 24-month follow-up. Results showed statistically significant differences in the Constant-Murley score at the primary endpoint of 6-months follow-up in favor of the treatment group. Researchers found no significant differences in clinical outcome measures at any of the other follow-up points. Researchers also noted no significant differences in re-rupture rate, complication rate and number of adverse events between the two groups.

“These results open new perspectives in the enhancement of rotator cuff repair, paving the way to a possibly accelerated return to pre-injury level of performance in the patients treated with autologous microfragmented adipose tissue, which could have a particularly relevant role in sports medicine, “Randelli said.

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